Evaluation of in vitro antileishmanial activity of curcumin and its derivatives "gallium curcumin, indium curcumin and diacethyle curcumin".
Identifieur interne : 000715 ( Main/Exploration ); précédent : 000714; suivant : 000716Evaluation of in vitro antileishmanial activity of curcumin and its derivatives "gallium curcumin, indium curcumin and diacethyle curcumin".
Auteurs : RBID : pubmed:24379060English descriptors
- KwdEn :
- Curcuma, Curcumin (analogs & derivatives), Curcumin (pharmacology), Dose-Response Relationship, Drug, Gallium (pharmacology), Indium (pharmacology), Inhibitory Concentration 50, Leishmania major (drug effects), Leishmania major (growth & development), Parasitic Sensitivity Tests, Phytotherapy, Plants, Medicinal, Trypanocidal Agents (pharmacology).
- MESH :
- chemical , analogs & derivatives : Curcumin.
- chemical , pharmacology : Curcumin, Gallium, Indium, Trypanocidal Agents.
- drug effects : Leishmania major.
- growth & development : Leishmania major.
- Curcuma, Dose-Response Relationship, Drug, Inhibitory Concentration 50, Parasitic Sensitivity Tests, Phytotherapy, Plants, Medicinal.
Abstract
Leishmania parasites are intracellular haemoflagellates that infect macrophages of the skin and viscera to produce diseases in their vertebrates hosts. Antileishmania therapy is based on pentavalent antimony compounds which toxicity of these agents and the persistence of side effects are severe. Curcumin was identified to be responsible for most of the biological effects of turmeric. Turmeric plant extracts (curcumin and other derivatives) have anti-inflammatory, anti-arthritic, antioxidant, anti-microbial, antileishmanial, hepato protective, anti-cancer, anti-ulcer and anti diabetic activity.
PubMed: 24379060
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of in vitro antileishmanial activity of curcumin and its derivatives "gallium curcumin, indium curcumin and diacethyle curcumin".</title><author><name sortKey="Fouladvand, M" uniqKey="Fouladvand M">M Fouladvand</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Parasitology, Faculty of Medicine, The Persian Gulf Tropical and Infectious Diseases Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. mfooladvand39@yahoo.com.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Microbiology and Parasitology, Faculty of Medicine, The Persian Gulf Tropical and Infectious Diseases Research Center, Bushehr University of Medical Sciences, Bushehr</wicri:regionArea></affiliation></author><author><name sortKey="Barazesh, A" uniqKey="Barazesh A">A Barazesh</name></author><author><name sortKey="Tahmasebi, R" uniqKey="Tahmasebi R">R Tahmasebi</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="RBID">pubmed:24379060</idno><idno type="pmid">24379060</idno><idno type="wicri:Area/Main/Corpus">000231</idno><idno type="wicri:Area/Main/Curation">000231</idno><idno type="wicri:Area/Main/Exploration">000715</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Curcuma</term><term>Curcumin (analogs & derivatives)</term><term>Curcumin (pharmacology)</term><term>Dose-Response Relationship, Drug</term><term>Gallium (pharmacology)</term><term>Indium (pharmacology)</term><term>Inhibitory Concentration 50</term><term>Leishmania major (drug effects)</term><term>Leishmania major (growth & development)</term><term>Parasitic Sensitivity Tests</term><term>Phytotherapy</term><term>Plants, Medicinal</term><term>Trypanocidal Agents (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Curcumin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Curcumin</term><term>Gallium</term><term>Indium</term><term>Trypanocidal Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Leishmania major</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Leishmania major</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Curcuma</term><term>Dose-Response Relationship, Drug</term><term>Inhibitory Concentration 50</term><term>Parasitic Sensitivity Tests</term><term>Phytotherapy</term><term>Plants, Medicinal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Leishmania parasites are intracellular haemoflagellates that infect macrophages of the skin and viscera to produce diseases in their vertebrates hosts. Antileishmania therapy is based on pentavalent antimony compounds which toxicity of these agents and the persistence of side effects are severe. Curcumin was identified to be responsible for most of the biological effects of turmeric. Turmeric plant extracts (curcumin and other derivatives) have anti-inflammatory, anti-arthritic, antioxidant, anti-microbial, antileishmanial, hepato protective, anti-cancer, anti-ulcer and anti diabetic activity.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24379060</PMID><DateCreated><Year>2013</Year><Month>12</Month><Day>31</Day></DateCreated><DateCompleted><Year>2014</Year><Month>03</Month><Day>27</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">1128-3602</ISSN><JournalIssue CitedMedium="Print"><Volume>17</Volume><Issue>24</Issue><PubDate><Year>2013</Year><Month>Dec</Month></PubDate></JournalIssue><Title>European review for medical and pharmacological sciences</Title><ISOAbbreviation>Eur Rev Med Pharmacol Sci</ISOAbbreviation></Journal><ArticleTitle>Evaluation of in vitro antileishmanial activity of curcumin and its derivatives "gallium curcumin, indium curcumin and diacethyle curcumin".</ArticleTitle><Pagination><MedlinePgn>3306-8</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">6173</ELocationID><Abstract><AbstractText Label="BACKGROUND AND OBJECTIVES" NlmCategory="OBJECTIVE">Leishmania parasites are intracellular haemoflagellates that infect macrophages of the skin and viscera to produce diseases in their vertebrates hosts. Antileishmania therapy is based on pentavalent antimony compounds which toxicity of these agents and the persistence of side effects are severe. Curcumin was identified to be responsible for most of the biological effects of turmeric. Turmeric plant extracts (curcumin and other derivatives) have anti-inflammatory, anti-arthritic, antioxidant, anti-microbial, antileishmanial, hepato protective, anti-cancer, anti-ulcer and anti diabetic activity.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Stock solutions of curcumin, indium curcumin, diacetylcurcumin and Gallium curcumin were made up in DMSO. From the each stock solution serial dilutions were made with phosphate buffered saline and 100 µl of each prepared concentration was added to each well of 96-well micro plate. All tests were performed in triplicate. Negative control only received RPMI-1640 medium with a parasite density of 106 parasites /ml and the positive control contained varying concentrations of standard antileishmania compound, Amphotericine B. MTT solution was prepared as 5 mg/ml in RPMI-1640 and 20 µl of this concentration was added to each well. Antileishmania effects of test agents and control were evaluated by using the MTT assay.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Mean growth inhibition of triplicate for each concentration of test agents and control were measured. The IC50 values for curcumin, gallium curcumin [ga (CUR) 3], indium curcumin [in (CUR)3], Diacethyle Curcumin (DAC ) and Amphotericine B were 38 µg/ml, 32 µg/ml, 26 µg/ml, 52 µg/ml and 20 µg/ml respectively. Indium curcumin [in (CUR) 3] with IC50 values of 26 µg/ml was more effective than other three test agents against Leishmania. Mean growth inhibition of triplicate for Amphotericine B as control drug, was 20 µg/ml.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Indium curcumin and Gallium curcumin complex showed more antileishmanial activity than curcumin and diacetylcurcumin and could be suitable candidates for further investigations.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fouladvand</LastName><ForeName>M</ForeName><Initials>M</Initials><Affiliation>Department of Microbiology and Parasitology, Faculty of Medicine, The Persian Gulf Tropical and Infectious Diseases Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. mfooladvand39@yahoo.com.</Affiliation></Author><Author ValidYN="Y"><LastName>Barazesh</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Tahmasebi</LastName><ForeName>R</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Eur Rev Med Pharmacol Sci</MedlineTA><NlmUniqueID>9717360</NlmUniqueID><ISSNLinking>1128-3602</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Trypanocidal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>045A6V3VFX</RegistryNumber><NameOfSubstance>Indium</NameOfSubstance></Chemical><Chemical><RegistryNumber>5PUQ5907YX</RegistryNumber><NameOfSubstance>diacetylcurcumin</NameOfSubstance></Chemical><Chemical><RegistryNumber>CH46OC8YV4</RegistryNumber><NameOfSubstance>Gallium</NameOfSubstance></Chemical><Chemical><RegistryNumber>IT942ZTH98</RegistryNumber><NameOfSubstance>Curcumin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Curcuma</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Curcumin</DescriptorName><QualifierName MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gallium</DescriptorName><QualifierName MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName><QualifierName MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Inhibitory Concentration 50</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Leishmania major</DescriptorName><QualifierName MajorTopicYN="Y">drug effects</QualifierName><QualifierName MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Parasitic Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Phytotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Plants, Medicinal</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Trypanocidal Agents</DescriptorName><QualifierName MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>3</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24379060</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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